High-affinity T cell receptors for adoptive cell transfer
نویسندگان
چکیده
منابع مشابه
“First AID” for T cell adoptive transfer: TCR affinity maturation by somatic hypermutation
Adoptive cell transfer (ACT) of tumor specific T lymphocytes, after host immunodepletion, was shown to mediate objective cancer regression of metastatic melanoma. Effective T cell activation depends, among other factors, on the functional avidity of the peptide-MHC complex (pMHC) to the T cell receptor (TCR), i.e. on the affinity and the number of pMHC-TCR contacts. Since the T cell repertoire ...
متن کاملT-cell-based Immunotherapy: Adoptive Cell Transfer and Checkpoint Inhibition.
Tumor immunotherapy has had demonstrable efficacy in patients with cancer. The most promising results have been with T-cell-based therapies. These include adoptive cell transfer of tumor-infiltrating lymphocytes, genetically engineered T cells, and immune checkpoint inhibitor antibodies. In this review, we describe the different T-cell-based strategies currently in clinical trials and put their...
متن کاملRole of T Cell Receptor Affinity in the Efficacy and Specificity of Adoptive T Cell Therapies
Over the last several years, there has been considerable progress in the treatment of cancer using gene modified adoptive T cell therapies. Two approaches have been used, one involving the introduction of a conventional αβ T cell receptor (TCR) against a pepMHC cancer antigen, and the second involving introduction of a chimeric antigen receptor (CAR) consisting of a single-chain antibody as an ...
متن کاملAbility of Different T Cell Sets to Transfer Adoptive
An animal that has previously encoun te red and reacted to antigen usually possesses an immune system poised to vigorously react to ano ther challenge of the same antigen. It is of ten the case, however, that the immune cells o f the pr imed animal are incapable o f funct ion when injected into an untreated, naive recipient. This barr ier to adoptive immune transfer first appears in mice a roun...
متن کاملFocus on Adoptive T Cell Transfer Trials in Melanoma
Adoptive Cell Transfer (ACT) of Tumor-Infiltrating Lymphocytes (TIL) in combination with lymphodepletion has proven to be an effective treatment for metastatic melanoma patients, with an objective response rate in 50%-70% of the patients. It is based on the ex vivo expansion and activation of tumor-specific T lymphocytes extracted from the tumor and their administration back to the patient. Var...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Journal of Clinical Investigation
سال: 2018
ISSN: 0021-9738,1558-8238
DOI: 10.1172/jci125471